Description

2-o-Acetyl-Malic Anhydride is a specialized organic anhydride derivative of malic acid, serving as a key chiral building block and reactive intermediate in advanced chemical synthesis. Its value lies in its ability to introduce protected malic acid moieties, enabling the controlled synthesis of complex molecules with high stereochemical fidelity. This compound is essential for research and production in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs), chiral catalysts, and novel polymeric materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of chiral drugs, prodrugs, and complex bioactive molecules.
• Asymmetric Synthesis: Used as a chiral auxiliary or building block for constructing stereodefined compounds in medicinal chemistry.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for producing specialty polyesters and polyanhydrides with tailored properties.
• Fine Chemical Production: Employed in the manufacture of flavors, fragrances, and advanced agrochemical intermediates.
• Bioconjugation & Proteomics: Potential use in modifying peptides or proteins due to its reactive anhydride group.
• Academic & R&D: A valuable reagent for methodological development in organic synthesis and catalysis research.

Basic Information

Product Name	2-o-Acetyl-Malic Anhydride
CAS No.	24766-96-9
Molecular Formula	C7H8O6
Molecular Weight	188.13 g/mol
Synonyms	2-Acetyloxy-succinic Anhydride; 2-(Acetyloxy)succinic Anhydride; Acetylmalic Anhydride; 2-O-Acetylmalic Anhydride; (3S)-3-(Acetyloxy)-2,5-dihydrofuran-2,5-dione; 2-Acetoxysuccinic Anhydride; Malic Acid 2-Acetate Anhydride; 2-O-Acetyl-L-malic Anhydride (for the L-enantiomer)
EINECS	Contact for details

Quality Control

Our 2-o-Acetyl-Malic Anhydride is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the exacting standards required for pharmaceutical and fine chemical applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent degradation by moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.