Description

(5S,8'R)-6',7,8,8'-Tetrahydro-6-Methyl-Spiro[1,3-Dioxolo[4,5-G]Isoquinoline-5(6H),7'-[7H]Indeno[4,5-D][1,3]Dioxol]-8'α-Ol is a complex spirocyclic organic compound with a defined stereochemistry, serving as a valuable chiral building block and intermediate in advanced organic synthesis. Its intricate fused ring system and specific stereocenter make it a critical precursor for the development of novel pharmacologically active molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of complex natural product analogs and targeted drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) targets.
• Asymmetric Synthesis: Utilized as a sophisticated starting material or intermediate in stereoselective chemical reactions to construct complex molecular architectures.
• Natural Product Analog Synthesis: Serves as a core structural motif for synthesizing analogs of biologically active natural products containing isoquinoline or indene frameworks.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs within drug discovery pipelines.
• Chemical Reference Standard: Used as a high-purity analytical standard for method development and quality control in research and development laboratories.
• Academic Research: Applied in university and institutional research exploring new synthetic methodologies and reaction mechanisms involving polycyclic systems.

Basic Information

Product Name	(5S,8'R)-6',7,8,8'-Tetrahydro-6-Methyl-Spiro[1,3-Dioxolo[4,5-G]Isoquinoline-5(6H),7'-[7H]Indeno[4,5-D][1,3]Dioxol]-8'α-Ol
CAS No.	24181-80-4
Molecular Formula	C₂₁H₂₁NO₅
Molecular Weight	367.40 g/mol
Synonyms	8'-Hydroxy-6-methyl-6',7,8,8'-tetrahydrospiro[1,3-dioxolo[4,5-g]isoquinoline-5(6H),7'-[7H]indeno[4,5-d][1,3]dioxole]; Spiro[1,3-dioxolo[4,5-g]isoquinoline-5(6H),7'-[7H]indeno[4,5-d][1,3]dioxole]-8'α-ol, 6',7,8,8'-tetrahydro-6-methyl-, (5S,8'R)-; (5S,8'R)-8'-Hydroxy-6-methyl-6',7,8,8'-tetrahydrospiro[1,3-dioxolo[4,5-g]isoquinoline-5(6H),7'-[7H]indeno[4,5-d][1,3]dioxole]; CAS 24181-80-4
EINECS	Contact for details

Quality Control

Our (5S,8'R)-6',7,8,8'-Tetrahydro-6-Methyl-Spiro[1,3-Dioxolo[4,5-G]Isoquinoline-5(6H),7'-[7H]Indeno[4,5-D][1,3]Dioxol]-8'α-Ol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.