Description

5-Hydroxybenzo[A]Pyrene is a hydroxylated derivative of the well-studied polycyclic aromatic hydrocarbon, benzo[a]pyrene. This compound is of significant interest in research and analytical chemistry, particularly for its role as a metabolite and biomarker of exposure to environmental carcinogens. It is primarily utilized by researchers and quality control laboratories in the environmental monitoring, toxicology, and pharmaceutical development sectors for method development, calibration, and reference standards.

Application

• Analytical Reference Standard: Used as a high-purity certified reference material (CRM) for the calibration of analytical instruments like HPLC, GC-MS, and LC-MS in environmental and biological sample analysis.
• Metabolite Studies: Serves as a critical standard in toxicological research to study the metabolic pathways, DNA adduct formation, and carcinogenic mechanisms of benzo[a]pyrene.
• Environmental Monitoring: Employed in the quantification and confirmation of polycyclic aromatic hydrocarbon (PAH) metabolites in soil, water, air particulate, and industrial effluent samples to assess pollution levels.
• Biomarker Research: Essential for developing and validating assays to detect and quantify human exposure to PAHs through biological monitoring (e.g., in urine or blood).
• Pharmaceutical Impurity Profiling: Can be used as a standard for impurity identification and method development in APIs where PAH contamination is a concern.
• Academic and Institutional Research: Supports fundamental chemical and biochemical research in universities and government institutions focused on organic chemistry, environmental health, and cancer research.

Basic Information

Product Name	5-Hydroxybenzo[A]Pyrene
CAS No.	24027-84-7
Molecular Formula	C₂₀H₁₂O
Molecular Weight	268.31 g/mol
Synonyms	5-Hydroxybenzo[a]pyrene; 5-Hydroxy-BaP; Benzo[a]pyren-5-ol; 5-HBP; 5-OH-BaP; Hydroxybenzo[a]pyrene; 1-Hydroxybenzo[a]pyrene (isomeric); PAH Metabolite Standard
EINECS	Contact for details

Quality Control

Every batch of 5-Hydroxybenzo[A]Pyrene is manufactured and handled under strict quality management protocols. We provide material suitable for use as an analytical standard, with purity typically verified by advanced chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing batch-specific purity, identity confirmation, and impurity profile is supplied with each shipment to ensure traceability and compliance with your research or quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere to minimize the risk of oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	≤ 2.0% total
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.