Description

4-Hydroxy-8-(Trifluoromethyl)Quinoline-3-Carboxylic Ethyl Ester is a high-value, multifunctional heterocyclic building block characterized by its quinoline core and trifluoromethyl group. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where the CF3 moiety is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in anti-infective and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides and fungicides, leveraging the bioactivity of the quinoline scaffold.
• Material Science Research: Used in the development of organic electronic materials, such as OLEDs and sensors, due to its electron-deficient aromatic structure.
• Ligand and Catalyst Development: Employed in the synthesis of nitrogen-containing ligands for metal catalysis in fine chemical production.
• Fluorinated Compound Library: An essential building block for creating diverse fluorinated compound libraries for high-throughput screening in drug discovery.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorescent probes or enzyme inhibitors for biochemical research.

Basic Information

Product Name	4-Hydroxy-8-(Trifluoromethyl)Quinoline-3-Carboxylic Ethyl Ester
CAS No.	23851-84-5
Molecular Formula	C13H10F3NO3
Molecular Weight	285.22 g/mol
Synonyms	Ethyl 4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate; 8-(Trifluoromethyl)-4-hydroxyquinoline-3-carboxylic acid ethyl ester; 4-Hydroxy-8-trifluoromethylquinoline-3-carboxylic acid ethyl ester; 3-Quinolinecarboxylic acid, 4-hydroxy-8-(trifluoromethyl)-, ethyl ester; 4-Hydroxy-8-trifluoromethyl-3-quinolinecarboxylic acid ethyl ester; Quinoline-3-carboxylic acid, 4-hydroxy-8-(trifluoromethyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-8-(Trifluoromethyl)Quinoline-3-Carboxylic Ethyl Ester is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.