Description

4-Hydroxy-8-(Trifluoromethyl)Quinoline-3-Carboxylic Acid is a high-value, multifunctional heterocyclic building block that serves as a critical intermediate in advanced organic synthesis. Its unique molecular structure, featuring both a carboxylic acid and a hydroxyquinoline core with a trifluoromethyl group, makes it indispensable for creating compounds with tailored biological and physical properties. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate fluorinated quinoline motifs into new active molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for anti-infective, anti-inflammatory, and anticancer agents, leveraging the bioactivity of the quinoline scaffold and the metabolic stability imparted by the trifluoromethyl group.
• Agrochemical Synthesis: Used in the development of next-generation pesticides and herbicides, where the fluorine atoms enhance lipophilicity, membrane permeability, and environmental stability of the active ingredient.
• Material Science Research: Serves as a building block for advanced organic materials, such as metal-organic frameworks (MOFs), organic semiconductors, and fluorescent dyes, due to its chelating and electron-withdrawing properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways in academic and industrial research settings.
• Coordination Chemistry: Acts as a versatile ligand for metal complexes, useful in catalysis and the creation of novel inorganic-organic hybrid materials.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global fine chemical market.

Basic Information

Product Name	4-Hydroxy-8-(Trifluoromethyl)Quinoline-3-Carboxylic Acid
CAS No.	23779-95-5
Molecular Formula	C11H6F3NO3
Molecular Weight	257.17 g/mol
Synonyms	8-(Trifluoromethyl)-4-hydroxyquinoline-3-carboxylic acid; 4-Hydroxy-8-trifluoromethylquinoline-3-carboxylic acid; 3-Quinolinecarboxylic acid, 4-hydroxy-8-(trifluoromethyl)-; 4-Hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate; 8-Trifluoromethyl-4-hydroxyquinoline-3-carboxylic acid; 4-Hydroxy-8-trifluoromethyl-3-quinolinecarboxylic acid; 23779-95-5; 4-Hydroxy-8-(trifluoromethyl)quinoline-3-carboxylic acid (primary name)
EINECS	Contact for details

Quality Control

Our production of 4-Hydroxy-8-(Trifluoromethyl)Quinoline-3-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is characterized and released against comprehensive specifications, including identity confirmation by spectroscopic methods and purity determination by HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We support compliance with global regulatory frameworks, including REACH, and can accommodate specific customer requirements for pharmaceutical (GMP) or other high-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.