Description

2-o-Methyl-α-D-n-Acetylneuraminic Acid CAS NO 23755-35-3 is a chemically modified derivative of N-acetylneuraminic acid, a key sialic acid. This compound is critical for advanced biochemical research and pharmaceutical development, particularly in the study of sialic acid metabolism, enzyme inhibition, and carbohydrate-based drug discovery. It serves as a valuable building block and reference standard for researchers in medicinal chemistry, glycobiology, and virology, enabling the synthesis of novel glycomimetics and the investigation of biological recognition processes.

Application

• Glycobiology Research: Used as a key intermediate and reference standard in studying sialic acid pathways, glycosylation, and cell surface recognition.
• Enzyme Inhibition Studies: Acts as a substrate analog for sialidases (neuraminidases) and sialyltransferases to investigate enzyme mechanisms and develop inhibitors.
• Pharmaceutical Development: Serves as a crucial building block for synthesizing novel glycomimetic drugs targeting influenza, other viral infections, and inflammatory diseases.
• Diagnostic Reagent Synthesis: Employed in the production of specialized reagents and probes for detecting sialic acid-binding proteins and pathogens.
• Bioconjugation & Labeling: Utilized to introduce modified sialic acid residues onto proteins, lipids, or nanoparticles for targeted delivery and imaging studies.
• Academic & Industrial R&D: Essential for basic research and applied projects in biotechnology and therapeutic discovery requiring high-purity, well-characterized sialic acid derivatives.

Basic Information

Product Name	2-o-Methyl-α-D-n-Acetylneuraminic Acid
CAS No.	23755-35-3
Molecular Formula	C12H21NO9
Molecular Weight	323.30 g/mol
Synonyms	2-O-Methyl-N-acetylneuraminic acid; 2-O-Methyl-Neu5Ac; Methyl 5-acetamido-3,5-dideoxy-2-O-methyl-D-glycero-α-D-galacto-non-2-ulopyranosidonic acid; 2-O-Methyl-α-D-N-acetylneuraminate; 2-OMe-Neu5Ac; 2-Methoxy-N-acetylneuraminic acid; Sialic acid 2-O-methyl derivative
EINECS	Contact for details

Quality Control

Our 2-o-Methyl-α-D-n-Acetylneuraminic Acid is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is thoroughly characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.