Description

n-[[(Diethoxyphosphinyl)Thio]Acetyl]-L-Valine Ethyl Ester is a specialized organophosphorus compound that serves as a critical chiral intermediate in advanced chemical synthesis. Its value lies in its unique structure, which incorporates both a phosphorothioate group and a protected L-valine moiety, making it essential for constructing complex molecules with high stereochemical fidelity. This product is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients, such as enzyme inhibitors and chiral ligands.

Application

• Key chiral intermediate in the synthesis of pharmaceutical active ingredients, particularly enzyme inhibitors and protease inhibitors.
• Building block for advanced agrochemicals, including the development of novel insecticides and herbicides with specific modes of action.
• Precursor in medicinal chemistry research for creating compound libraries and exploring structure-activity relationships (SAR).
• Intermediate for the preparation of chiral ligands used in asymmetric catalysis and transition metal complexes.
• Starting material for biochemical research involving acetylcholinesterase and other esterase studies.
• Specialty reagent for custom synthesis and contract manufacturing organizations (CMOs) serving the life sciences industry.

Basic Information

Product Name	n-[[(Diethoxyphosphinyl)Thio]Acetyl]-L-Valine Ethyl Ester
CAS No.	23701-49-7
Molecular Formula	C13H26NO6PS
Molecular Weight	355.39 g/mol
Synonyms	L-Valine, N-[[(diethoxyphosphinyl)thio]acetyl]-, ethyl ester; Ethyl N-[(diethoxyphosphinothioyl)thioacetyl]-L-valinate; O,O-Diethyl S-[2-(ethoxycarbonyl)-1-methylpropylcarbamoyl]methyl phosphorothioate; Acetyl-L-valine ethyl ester phosphorothioate derivative; NSC 332888; Phosphorothioic acid, [[(1-ethoxycarbonyl)-2-methylpropyl]amino]oxomethyl]-, diethyl ester; Diethyl ((((1-ethoxy-3-methyl-1-oxobutan-2-yl)amino)oxomethyl)thio)phosphonate
EINECS	Contact for details

Quality Control

Our n-[[(Diethoxyphosphinyl)Thio]Acetyl]-L-Valine Ethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is light-sensitive and easily oxidized; prolonged exposure to air, light, or moisture should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.