Description

4-Deoxy-D-Glucose is a synthetic monosaccharide derivative where the hydroxyl group at the C-4 position is replaced by hydrogen. This structural modification makes it a valuable biochemical tool for studying carbohydrate metabolism and transport mechanisms. It is primarily utilized by researchers and manufacturers in the life sciences, pharmaceutical development, and diagnostic sectors. Its role as a metabolic inhibitor is critical for investigating glucose-related pathways.

Application

• Biochemical Research: Used as a non-metabolizable glucose analog to study glucose transport, hexokinase activity, and glycolysis inhibition in cell culture and enzymatic assays.
• Pharmaceutical Development: Serves as a reference standard or intermediate in the research of metabolic disorders, such as diabetes and cancer, where glucose uptake is a therapeutic target.
• Diagnostic Agent Research: Investigated for potential use in imaging studies to track altered glucose metabolism in tissues.
• Microbiology Studies: Applied in research to understand sugar metabolism and energy production in various microbial systems.
• Enzymology: Acts as a substrate analog for enzymes like glucokinase and glucose-6-phosphate dehydrogenase to probe enzyme specificity and mechanism.
• Cell Biology: Employed to induce metabolic stress and study cellular responses like autophagy and apoptosis under glucose-deprivation-like conditions.

Basic Information

Product Name	4-Deoxy-D-Glucose
CAS No.	23397-23-1
Molecular Formula	C6H12O5
Molecular Weight	164.16 g/mol
Synonyms	4-Deoxy-D-glucose; 4-Deoxyglucose; D-4-Deoxyglucose; 4-Desoxy-D-glucose; 6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,5-triol; (2R,3S,5R,6S)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,5-triol
EINECS	Contact for details

Quality Control

Our 4-Deoxy-D-Glucose is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets high-purity research-grade standards. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.