Description

trans-4-Methyl-L-Proline is a non-proteinogenic, chiral proline derivative characterized by a methyl group at the 4-position of the pyrrolidine ring. This compound is a valuable chiral building block and intermediate in organic synthesis, prized for its ability to induce conformational constraints and influence peptide secondary structure. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptide mimetics, and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting neurological and metabolic disorders.
• Peptide Chemistry: Used to modify peptide backbones to enhance stability, bioavailability, and biological activity by introducing conformational constraints.
• Asymmetric Catalysis: Serves as a precursor or ligand in the development of chiral catalysts for stereoselective synthesis.
• Biochemical Research: Employed as a tool compound in enzymology and molecular biology studies to probe protein structure and function.
• Agrochemical Synthesis: An intermediate in the development of advanced, chiral agrochemicals such as herbicides and fungicides.
• Material Science: A building block for specialty polymers and advanced materials requiring specific chiral architectures.

Basic Information

Product Name	trans-4-Methyl-L-Proline
CAS No.	23009-50-9
Molecular Formula	C6H11NO2
Molecular Weight	129.16 g/mol
Synonyms	(2S,4S)-4-Methylpyrrolidine-2-carboxylic acid; L-4-Methylproline; (2S,4S)-4-Methylproline; 4-Methyl-L-proline; trans-4-Methyl-L-proline; (S,S)-4-Methylproline; 4-Methyl-(S)-proline; 4-Methyl-L-azetidine-2-carboxylic acid (obsolete)
EINECS	Contact for details

Quality Control

Our trans-4-Methyl-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and fine chemical synthesis. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic results (NMR, IR) are provided to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.