Description

n-Cbz-3,4-Dihydro-1H-Isoquinolinecarboxylic Acid is a protected amino acid derivative, specifically a benzyloxycarbonyl (Cbz)-protected tetrahydroisoquinoline carboxylic acid, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in providing a versatile and reactive scaffold for constructing complex pharmaceutical intermediates and bioactive molecules. This high-purity intermediate is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries engaged in peptide mimetics and heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of drug candidates targeting neurological disorders, cardiovascular diseases, and oncology.
• Peptidomimetics & Constrained Peptides: Used to introduce rigid, bicyclic tetrahydroisoquinoline scaffolds into peptide backbones to enhance metabolic stability and receptor selectivity.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations to create enantiomerically pure compounds.
• Agrochemical Research: Intermediate in the development of novel herbicides, fungicides, and plant growth regulators with specific chiral centers.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	n-Cbz-3,4-Dihydro-1H-Isoquinolinecarboxylic Acid
CAS No.	22914-95-0
Molecular Formula	C18H17NO4
Molecular Weight	311.33 g/mol
Synonyms	1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, N-[(benzyloxy)carbonyl]-; N-Carbobenzoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; N-Cbz-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; (S)-N-Cbz-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acid (for enantiopure form); Z-Tic-OH; CBZ-TIC-OH; 3-Carboxy-1,2,3,4-tetrahydroisoquinoline, N-carbobenzoxy derivative
EINECS	Contact for details

Quality Control

Every batch of n-Cbz-3,4-Dihydro-1H-Isoquinolinecarboxylic Acid is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) detailing purity, chiral purity (where applicable), and impurity profiles are available for each lot. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.