Description

Cyclopropanecarboxylic Acid, 2-Nitro-, (1R,2R)-Rel- (9Ci) is a high-value, stereochemically defined chiral building block of significant interest in advanced organic synthesis. This compound matters because its unique cyclopropane ring fused with a nitro and carboxylic acid functional group provides a rigid, strained scaffold for constructing complex molecules with precise three-dimensional control. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, asymmetric synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Asymmetric Synthesis: Utilized as a precursor or reagent in stereoselective reactions, including cycloadditions and nucleophilic substitutions, to introduce the chiral cyclopropane motif.
• Medicinal Chemistry & SAR Studies: Serves as a core scaffold for structure-activity relationship (SAR) explorations due to its constrained geometry and potential for diverse derivatization.
• Agrochemical Research: Employed in the synthesis of advanced crop protection agents and herbicides where the cyclopropane structure can enhance biological activity and stability.
• Ligand and Catalyst Development: Used in the preparation of chiral ligands and organocatalysts for enantioselective transformations.
• Material Science Precursor: Investigated for the synthesis of specialized polymers and advanced materials with unique thermal or mechanical properties.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-Nitro-, (1R,2R)-Rel- (9Ci)
CAS No.	22882-43-5
Molecular Formula	C4H5NO4
Molecular Weight	131.09 g/mol
Synonyms	(1R,2R)-2-Nitrocyclopropanecarboxylic Acid; rel-(1R,2R)-2-Nitrocyclopropanecarboxylic Acid; (1R,2R)-rel-2-Nitrocyclopropanecarboxylic Acid; 2-Nitrocyclopropanecarboxylic Acid, (1R,2R)-rel-; (R,R)-2-Nitrocyclopropanecarboxylic Acid (relative configuration); trans-2-Nitrocyclopropanecarboxylic Acid (relative configuration)
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 2-Nitro-, (1R,2R)-Rel- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider holding under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (rel-(1R,2R))
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.