Description

1-Bromo-4-(tert-Butoxymethyl)Benzene is a high-purity aromatic building block featuring a bromine substituent and a tert-butoxymethyl protecting group. This compound is valued for its role as a versatile intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in cross-coupling reactions and as a protected benzyl alcohol precursor.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides, where its aromatic bromine is a reactive handle for further functionalization.
• Ligand and Catalyst Development: Employed as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and homogeneous catalysis.
• Material Science Research: Acts as a monomer or functionalization agent in the development of novel polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Utilized in the synthesis of molecular probes, affinity tags, and other tools for studying biological systems and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Item	Details
Product Name	1-Bromo-4-(tert-Butoxymethyl)Benzene
CAS No.	22807-80-3
Molecular Formula	C11H15BrO
Molecular Weight	243.14 g/mol
Synonyms	4-Bromobenzyl tert-Butyl Ether; 1-Bromo-4-[(2-methyl-2-propanyl)oxy]methyl]benzene; p-Bromobenzyl tert-Butyl Ether; (4-Bromophenyl)methanol, 1-(1,1-dimethylethyl) ether; tert-Butyl 4-Bromobenzyl Ether; 4-(tert-Butoxymethyl)bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(tert-Butoxymethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.