Description

o-(Trimethylsilyl)Hydroxylamine is a versatile organosilicon reagent featuring a protected hydroxylamine functional group. This compound is critical for introducing the N-O moiety into complex molecules under mild conditions, enabling precise synthetic transformations. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as heterocycle synthesis and polymer modification.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of oximes, hydroxamic acids, and N-oxide containing drug candidates.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides that require N-O functional groups.
• Polymer Modification: Serves as a functionalizing agent to introduce amine oxide groups into polymer chains, altering surface properties.
• Heterocyclic Chemistry: Essential reagent for constructing isoxazoles, isoxazolines, and other nitrogen-oxygen heterocycles.
• Protecting Group Strategy: The trimethylsilyl group acts as a protective moiety for hydroxylamine in multi-step organic syntheses.
• Material Science Research: Employed in surface functionalization of silicon-based materials and nanoparticles.

Basic Information

Product Name	o-(Trimethylsilyl)Hydroxylamine
CAS No.	22737-36-6
Molecular Formula	C3H11NOSi
Molecular Weight	105.21 g/mol
Synonyms	O-Trimethylsilylhydroxylamine; N-(Trimethylsilyl)hydroxylamine; Hydroxylamine O-trimethylsilyl ether; TMSONH2; Trimethylsilyloxyamine; O-(TMS)hydroxylamine; N-(Trimethylsiloxy)amine; O-TMS-hydroxylamine
EINECS	Contact for details

Quality Control

Our o-(Trimethylsilyl)Hydroxylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including GC, NMR, and Karl Fischer titration to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for all commercial and research quantities, supporting compliance with cGMP and ISO standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C. Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 3.0%
Density (at 20°C)	~0.88 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.