Description

(-)-1,4-Anhydro-L-Threitol CAS NO 22554-74-1 is a high-purity, chiral anhydro sugar alcohol derivative of L-threitol. This compound serves as a valuable chiral building block and intermediate in sophisticated organic synthesis, particularly for the construction of complex molecules with defined stereochemistry. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries developing active ingredients, ligands, and specialty polymers.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of nucleoside analogs, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and plant growth regulators requiring specific stereochemical configurations.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal complexation.
• Fine Chemical Production: Building block for specialty chemicals, flavors, fragrances, and advanced materials.
• Biochemical Research: Utilized in enzymatic studies and as a standard or reagent in carbohydrate chemistry research.
• Polymer Science: Monomer or cross-linking agent for synthesizing novel biodegradable or functional polymers.

Basic Information

Product Name	(-)-1,4-Anhydro-L-Threitol
CAS No.	22554-74-1
Molecular Formula	C4H8O3
Molecular Weight	104.10 g/mol
Synonyms	1,4-Anhydro-L-threitol; L-1,4-Anhydrothreitol; (-)-1,4-Anhydro-L-threitol; (2S,3S)-2,3-Dihydroxytetrahydrofuran; L-Threitol 1,4-anhydride; Tetrahydro-2,3-furandiol, (2S,3S)-; L-Anhydrothreitol; 2,3-Dihydroxytetrahydrofuran (L-form)
EINECS	Contact for details

Quality Control

Our (-)-1,4-Anhydro-L-Threitol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, specific rotation, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation [α]	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.