Description

Bicyclo[1.1.1]pentan-1-ylmethanol is a highly strained, cage-like organic alcohol that serves as a valuable and versatile building block in advanced organic synthesis. Its unique three-dimensional structure, featuring a [1.1.1]propellane core, makes it a critical intermediate for introducing rigid, sterically defined motifs into target molecules. This compound is essential for researchers and process chemists in pharmaceutical, agrochemical, and materials science R&D, enabling the development of novel compounds with tailored properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of bioisosteres, particularly for replacing aromatic rings or tert-butyl groups to improve metabolic stability, solubility, and physicochemical properties of drug candidates.
• Agrochemical Synthesis: Used to create novel active ingredients with enhanced efficacy and environmental profiles by incorporating its rigid, three-dimensional scaffold.
• Materials Science: Building block for high-performance polymers, liquid crystals, and metal-organic frameworks (MOFs) where its unique geometry can impart specific mechanical or optical properties.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed as a linker or spacer component due to its stability and defined spatial orientation.
• Cross-Coupling Reactions: Serves as a substrate in various metal-catalyzed transformations (e.g., Suzuki, Sonogashira) to create complex molecular architectures.
• Academic & Industrial Research: Fundamental reagent for exploring new synthetic methodologies and reaction pathways involving strained hydrocarbon systems.

Basic Information

Item	Details
Product Name	Bicyclo[1.1.1]pentan-1-ylmethanol
CAS No.	22287-32-7
Molecular Formula	C7H12O
Molecular Weight	112.17 g/mol
Synonyms	(1-Hydroxymethyl)bicyclo[1.1.1]pentane; Bicyclo[1.1.1]pentane-1-methanol; [1.1.1]Propellane-1-methanol; 1-(Hydroxymethyl)bicyclo[1.1.1]pentane; BCP-methanol; 1-Bicyclo[1.1.1]pentylmethanol
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]pentan-1-ylmethanol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.