Description

2-Chloro-3-Nitro-5-(Trifluoromethyl)Benzoic Acid is a high-value, multi-functional aromatic building block characterized by its unique trifluoromethyl and nitro substituents. This compound is essential for the synthesis of advanced agrochemicals and pharmaceuticals, where its structure imparts critical biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, agrochemical, and pharmaceutical industries for creating novel active ingredients and intermediates.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of advanced herbicides and pesticides, leveraging the bioactivity of the trifluoromethyl and nitro groups.
• Pharmaceutical Building Block: Used in medicinal chemistry for the research and development of new drug candidates, particularly in areas requiring fluorinated motifs.
• Fine Chemical Synthesis: Serves as a versatile intermediate for constructing complex molecules in custom synthesis and contract manufacturing.
• Material Science Research: Employed in the development of specialty chemicals, dyes, and functional materials that require specific electronic properties.
• Cross-Coupling Reactions: The halogen and carboxylic acid functionalities make it a suitable substrate for various metal-catalyzed coupling reactions.

Basic Information

Product Name	2-Chloro-3-Nitro-5-(Trifluoromethyl)Benzoic Acid
CAS No.	22227-59-4
Molecular Formula	C8H3ClF3NO4
Molecular Weight	269.56 g/mol
Synonyms	2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid; Benzoic acid, 2-chloro-3-nitro-5-(trifluoromethyl)-; 3-Nitro-2-chloro-α,α,α-trifluoro-p-toluic acid; 5-(Trifluoromethyl)-2-chloro-3-nitrobenzoic acid; 2-Chloro-α,α,α-trifluoro-3-nitro-p-toluic acid; 2-Chloro-3-nitro-5-trifluoromethylbenzoic acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Nitro-5-(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.