Description

n-Acetyl-A-Neuraminic Acid CAS NO 21646-00-4 is a high-purity sialic acid derivative, a critical monosaccharide component of glycoproteins and glycolipids. This compound serves as a fundamental building block and reference standard in glycobiology research and biopharmaceutical development. It is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and life science industries working on carbohydrate-based drugs, vaccine development, and cell surface interaction studies.

Application

• Biopharmaceutical Synthesis: Key intermediate and precursor in the synthesis of complex carbohydrate-based therapeutics, including antiviral drugs and cancer vaccines.
• Glycobiology Research: Essential substrate and standard for studying sialylation processes, cell-cell recognition, and pathogen-host interactions.
• Diagnostic Reagent Production: Used in the formulation of enzymatic assay kits and reagents for detecting sialidase activity and related biomarkers.
• Cell Culture & Media Supplement: Employed in specialized cell culture media to influence cell surface glycosylation patterns for research and production.
• Nutritional Science: Investigated as a potential bioactive ingredient in infant formula and nutraceuticals due to its presence in human milk oligosaccharides.
• Enzymology Studies: Serves as a specific substrate for sialyltransferases and neuraminidases (sialidases) in kinetic and inhibition studies.

Basic Information

Product Name	n-Acetyl-A-Neuraminic Acid
CAS No.	21646-00-4
Molecular Formula	C11H19NO9
Molecular Weight	309.27 g/mol
Synonyms	N-Acetylneuraminic Acid; Neu5Ac; Sialic Acid (N-acetyl form); 5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic Acid; NANA; Aceneuramic Acid; N-Acetyl-D-neuraminic Acid; O-Sialic Acid
EINECS	244-499-7

Quality Control

Our n-Acetylneuraminic Acid is produced under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, specific rotation, and residual solvent analysis, to ensure it meets the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided and traceable to reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed when not in use to prevent absorption of moisture from the atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Specific Rotation [α]20/D	-30.0° to -35.0° (c=1 in H2O)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Bacterial Endotoxins	< 0.5 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.