Description

1-(p-Tosyloxy)-3-Phenyl-2-Propyne is a specialized organic building block featuring a tosyl-protected propargylic alcohol moiety. This compound is valued for its role as a versatile electrophilic intermediate in advanced organic synthesis, enabling the introduction of the 3-phenyl-2-propynyl group. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, including heterocycles and bioactive compounds.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a precursor in the synthesis of specialized polymers and advanced organic materials.
• Cross-Coupling Reactions: An effective electrophile in Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Ligand and Catalyst Development: Building block for creating novel phosphine or N-heterocyclic carbene (NHC) ligands.
• Academic & Industrial R&D: Essential for methodological studies in synthetic organic chemistry and process development.

Basic Information

Product Name	1-(p-Tosyloxy)-3-Phenyl-2-Propyne
CAS No.	21541-60-6
Molecular Formula	C₁₆H₁₄O₃S
Molecular Weight	286.35 g/mol
Synonyms	3-Phenyl-2-propynyl p-toluenesulfonate; 3-Phenylprop-2-yn-1-yl 4-methylbenzenesulfonate; 1-(Tosyloxy)-3-phenyl-2-propyne; p-Toluenesulfonic acid 3-phenyl-2-propynyl ester; Tosyloxy(phenyl)propyne; Propargyl tosylate derivative
EINECS	Contact for details

Quality Control

Our production of 1-(p-Tosyloxy)-3-Phenyl-2-Propyne adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profile is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.