Description

Dihydronarwedine is a key intermediate in the synthesis of galantamine, a clinically significant acetylcholinesterase inhibitor. This compound matters for its role in producing high-purity active pharmaceutical ingredients (APIs) used in neurological therapeutics. It is primarily needed by pharmaceutical manufacturers and advanced research institutions focused on developing treatments for Alzheimer's disease and related cognitive disorders.

Application

• Pharmaceutical Intermediate: Critical precursor in the multi-step synthesis of galantamine hydrobromide and related salts.
• Neurological Drug Research: Used in R&D for developing and scaling up new acetylcholinesterase inhibitors.
• Reference Standard: Serves as a high-purity analytical standard for quality control in API manufacturing.
• Process Chemistry: Employed in process development and optimization for galantamine production routes.
• Academic Research: Utilized in university and institutional studies on alkaloid chemistry and neuropharmacology.

Basic Information

Product Name	Dihydronarwedine
CAS No.	21041-10-1
Molecular Formula	C17H21NO3
Molecular Weight	287.35 g/mol
Synonyms	Dihydronarwedine; Narwedine Dihydro Derivative; (4aS,6R,8aS)-6-Hydroxy-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol; Galantamine Intermediate; Dihydro-narwedine; Narwedine Dihydro; 21041-10-1
EINECS	Contact for details

Quality Control

Our Dihydronarwedine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.