Description

H-Glu(Oall)-Oall p-Tosylate is a protected glutamic acid derivative, specifically the bis-allyl ester tosylate salt of glutamic acid. This compound is a crucial building block in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS) methodologies, where it provides orthogonal protection for the side-chain carboxylic acid group. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers involved in the development of novel peptides, peptidomimetics, and bioconjugates. The CAS number for this compound is 20845-16-3.

Application

• Peptide Synthesis: Serves as a key protected amino acid precursor for the controlled incorporation of glutamic acid into peptide chains, especially in Fmoc/t-Bu and Boc/Bzl strategies.
• Pharmaceutical Research: Used in the R&D of therapeutic peptides where glutamic acid residues are required, enabling the synthesis of complex peptide-based drug candidates.
• Bioconjugation Chemistry: The allyl ester protecting groups can be selectively removed under mild, orthogonal conditions, allowing for subsequent site-specific modification or labeling of the peptide.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides used as tools for studying enzyme function, protein-protein interactions, and cellular processes.
• Fine Chemical Intermediate: Acts as a specialized intermediate for the custom synthesis of complex organic molecules and advanced materials requiring protected amino acid motifs.

Basic Information

Product Name	H-Glu(Oall)-Oall p-Tosylate
CAS No.	20845-16-3
Molecular Formula	C19H25NO7S
Molecular Weight	411.47 g/mol
Synonyms	L-Glutamic acid, 1,5-bis(2-propen-1-yl) ester, 4-methylbenzenesulfonate; H-Glu(OAll)-OAll·TosOH; Glutamic acid bis(allyl ester) p-toluenesulfonate salt; Fmoc-Glu(OAll)-OH precursor; Boc-Glu(OAll)-OH precursor; (S)-2,5-Bis(allyloxy)-5-oxopentan-1-aminium 4-methylbenzenesulfonate; Protected L-glutamic acid allyl ester tosylate
EINECS	Contact for details

Quality Control

Our H-Glu(Oall)-Oall p-Tosylate is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.