Description

1-O,2-O,3-O,4-O,5-O,6-o-Hexamethyl-D-Mannitol is a fully methylated derivative of the sugar alcohol D-mannitol, serving as a key protected intermediate in synthetic organic chemistry. This compound matters for its role in facilitating complex carbohydrate synthesis by providing a stable, non-reactive scaffold for selective deprotection and further functionalization. It is primarily needed by research institutions and pharmaceutical companies developing novel glycoconjugates, surfactants, or specialty polymers where precise control over hydroxyl group reactivity is critical.

Application

• Pharmaceutical Intermediate: Acts as a protected building block for the synthesis of complex carbohydrate-based drugs, prodrugs, and diagnostic agents.
• Glycochemistry Research: Serves as a standard or starting material in academic and industrial research for studying glycosylation reactions and carbohydrate transformations.
• Surfactant & Polymer Synthesis: Used as a hydrophobe or a core unit in the development of non-ionic surfactants, dendrimers, and specialty polymers with tailored solubility properties.
• Chiral Auxiliary/Resolving Agent: Potential use as a chiral template or resolving agent in asymmetric synthesis due to its defined stereochemistry.
• Analytical Standard: Employed as a reference standard in chromatographic (HPLC, GC) and spectroscopic methods for quality control and method development.

Basic Information

Product Name	1-O,2-O,3-O,4-O,5-O,6-o-Hexamethyl-D-Mannitol
CAS No.	20746-37-6
Molecular Formula	C12H26O6
Molecular Weight	266.33 g/mol
Synonyms	Hexa-O-methyl-D-mannitol; D-Mannitol, hexamethyl ether; 1,2,3,4,5,6-Hexa-O-methyl-D-mannitol; D-Mannitol hexamethyl ether; Per-O-methyl-D-mannitol; Hexamethyl mannitol; Mannitol hexamethyl ether; NSC 404088
EINECS	Contact for details

Quality Control

Our 1-O,2-O,3-O,4-O,5-O,6-o-Hexamethyl-D-Mannitol is produced and handled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identity confirmation by IR and NMR, purity assessment by HPLC or GC, and specific tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 98.0%
Melting Point	Specified range provided on COA
Specific Rotation	Specified range provided on COA
Loss on Drying	≤ 0.5%
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.