Description

3-Chloro-5-Isoxazolecarboxylic Acid (Saltdata: Free) is a high-purity heterocyclic carboxylic acid building block essential for advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecules, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the unique isoxazole pharmacophore into their target structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in antimicrobial, anti-inflammatory, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of modern herbicides, fungicides, and insecticides that leverage the isoxazole ring for bioactivity.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Material Science Precursor: Potential intermediate for the synthesis of specialty polymers, ligands for catalysis, or functionalized organic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	3-Chloro-5-Isoxazolecarboxylic Acid (Saltdata: Free)
CAS No.	20724-56-5
Molecular Formula	C4H2ClNO3
Molecular Weight	147.52 g/mol
Synonyms	3-Chloro-1,2-oxazole-5-carboxylic acid; 3-Chloro-5-carboxyisoxazole; 5-Isoxazolecarboxylic acid, 3-chloro-; 3-Chloroisoxazole-5-carboxylic acid; 3-Chloro-5-isoxazolecarboxylic acid (Free Acid); 20724-56-5; 3-Chloro-5-isoxazolylcarboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Isoxazolecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.