Description

(α-Hydroxy-4-Chlorobenzyl)Phosphonic Acid Diethyl Ester is a specialized organophosphorus compound that serves as a valuable synthetic intermediate and ligand in advanced chemical synthesis. Its unique structure, featuring both phosphonate ester and benzylic hydroxyl groups, makes it a versatile building block for creating complex molecules with tailored properties. This high-purity chemical is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting bone-related disorders or requiring phosphonate-based bioisosteres.
• Agrochemical Synthesis: Building block for developing advanced herbicides, plant growth regulators, and other crop protection agents with specific modes of action.
• Ligand in Catalysis: Used as a chelating ligand in transition metal catalysis for asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Intermediate for creating functionalized polymers, surface modifiers, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design of enzyme inhibitors and molecular probes to study biochemical pathways.
• Flame Retardant Synthon: Serves as a starting material for synthesizing phosphorus-containing flame retardant additives.

Basic Information

Product Name	(α-Hydroxy-4-Chlorobenzyl)Phosphonic Acid Diethyl Ester
CAS No.	20641-28-5
Molecular Formula	C11H16ClO4P
Molecular Weight	278.67 g/mol
Synonyms	Diethyl (α-Hydroxy-4-chlorobenzyl)phosphonate; (4-Chloro-α-hydroxybenzyl)phosphonic Acid Diethyl Ester; Diethyl (4-Chloro-α-hydroxybenzyl)phosphonate; (α-Hydroxy-p-chlorobenzyl)phosphonic Acid Diethyl Ester; Phosphonic Acid, P-[(4-chlorophenyl)(hydroxy)methyl]-, Diethyl Ester; Diethyl (hydroxy(4-chlorophenyl)methyl)phosphonate; 20641-28-5; NSC 163063
EINECS	Contact for details

Quality Control

Our (α-Hydroxy-4-Chlorobenzyl)Phosphonic Acid Diethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as oxidizing agents. The container must be kept tightly sealed due to sensitivity to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Chloride Content	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.