Description

1,1'-[Sulfonylbis(4,1-Phenylene)]Bisbiguanide is a high-purity bisbiguanide compound, also known by its common name, Chlorhexidine Impurity A. This substance serves as a critical pharmaceutical reference standard and a key intermediate in the synthesis of antiseptic agents. It is primarily required by manufacturers and quality control laboratories in the pharmaceutical, personal care, and disinfectant industries for research, development, and analytical purposes.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of Chlorhexidine-related impurities in drug substances and finished products, ensuring compliance with pharmacopeial monographs (USP, EP, BP).
• Active Pharmaceutical Ingredient (API) Intermediate: A vital synthetic precursor in the manufacturing of Chlorhexidine and its salts (e.g., Chlorhexidine Digluconate, Chlorhexidine Dihydrochloride).
• Analytical Research & Method Development: Employed in HPLC, LC-MS, and other chromatographic methods for method validation, stability studies, and impurity profiling.
• Disinfectant & Antiseptic Formulation: As a related substance of Chlorhexidine, it is relevant for quality control in the production of surgical scrubs, mouthwashes, wound cleansers, and skin antiseptics.
• Academic & Contract Research: Serves as a research chemical for studying the properties, stability, and degradation pathways of bisbiguanide antimicrobial compounds.

Basic Information

Item	Details
Product Name	1,1'-[Sulfonylbis(4,1-Phenylene)]Bisbiguanide
CAS No.	20566-97-6
Molecular Formula	C22H30Cl2N10O2S
Molecular Weight	577.52 g/mol
Synonyms	Chlorhexidine Impurity A; 1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide] Sulfone; N,N''-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine Sulfone; Bisbiguanide Sulfone Derivative; Chlorhexidine Related Compound A; 4,4'-(Hexamethylenediimino)di(benzenesulfonylbiguanide); 1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane Sulfone
EINECS	Contact for details

Quality Control

Our 1,1'-[Sulfonylbis(4,1-Phenylene)]Bisbiguanide is produced under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation against a certified reference standard. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific results for all critical parameters. Our quality commitment ensures the material is suitable for its intended use as a pharmaceutical impurity reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.