Description

(R)-(+)-α-Methoxy-α-Trifluoromethylphenylacetic Acid is a high-value chiral derivatizing agent and resolving acid, widely recognized for its utility in enantiomeric analysis and synthesis. Its core value lies in its ability to form stable diastereomeric derivatives with chiral amines and alcohols, enabling precise determination of enantiomeric purity via NMR or HPLC. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require rigorous stereochemical control and analytical verification.

Application

• Chiral Derivatizing Agent (CDA): For the determination of enantiomeric excess (ee) of chiral amines, amino alcohols, and alcohols via 19F or 1H NMR spectroscopy.
• Chiral Resolution: As a resolving acid for the separation of racemic mixtures of basic compounds through diastereomeric salt formation.
• Pharmaceutical Intermediate: In the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl groups.
• Analytical Standard: Used as a reference standard in chromatographic methods (HPLC, GC) for method development and validation in quality control labs.
• Asymmetric Synthesis: As a precursor or auxiliary in the construction of complex molecules requiring high enantioselectivity.
• Agrochemical Research: For the development and analysis of chiral pesticides and herbicides.

Basic Information

Product Name	(R)-(+)-α-Methoxy-α-Trifluoromethylphenylacetic Acid
CAS No.	20445-31-2
Molecular Formula	C11H9F3O3
Molecular Weight	246.18 g/mol
Synonyms	(R)-(+)-MTPA; (R)-Mosher's Acid; (R)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid; (R)-Methoxy(trifluoromethyl)phenylacetic acid; (R)-O-Methylmandelic acid α-trifluoromethyl derivative; (2R)-2-Methoxy-2-(trifluoromethyl)-2-phenylacetic acid; (R)-MTPA-OH; (R)-(-)-MTPA (Note: This is a common misnomer, the correct sign for the specific rotation of the (R)-enantiomer is positive).
EINECS	Contact for details

Quality Control

Our (R)-(+)-α-Methoxy-α-Trifluoromethylphenylacetic Acid is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for enantiomeric analysis and synthesis. Certificates of Analysis (COA) detailing specific optical rotation, chemical purity (by titration or HPLC), and enantiomeric excess are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Specific Optical Rotation [α]D20	+70° to +76° (c=1, CHCl3)
Melting Point	86 - 90 °C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.