Description

5-Thio-D-Glucose is a synthetic thio-sugar analog of D-glucose where the ring oxygen is replaced by a sulfur atom. This structural modification confers unique biochemical properties, making it a valuable tool compound for metabolic research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the life sciences, pharmaceutical, and biotechnology sectors for investigating glucose metabolism, cellular transport mechanisms, and as a potential lead compound for therapeutic agents.

Application

• Biochemical Research: Used as a potent, non-metabolizable competitive inhibitor of glucose transporters (GLUTs) to study cellular glucose uptake and metabolism.
• Pharmaceutical Development: Investigated as a potential therapeutic agent in metabolic disorders, such as diabetes and obesity, due to its ability to modulate glucose utilization.
• Oncology Research: Studied for its potential anti-cancer properties, as inhibiting glucose transport can selectively target the high glycolytic activity of tumor cells (Warburg effect).
• Enzymology Studies: Serves as a substrate analog to probe the active sites and mechanisms of glycosidases and other carbohydrate-processing enzymes.
• Microbiology: Used in studies of bacterial sugar metabolism and as a selective agent in microbial growth media.
• Diagnostic Reagent Synthesis: Acts as a key intermediate or reference standard in the development of diagnostic assays related to carbohydrate metabolism.

Basic Information

Product Name	5-Thio-D-Glucose
CAS No.	20408-97-3
Molecular Formula	C6H12O5S
Molecular Weight	196.22 g/mol
Synonyms	5-Thio-D-glucopyranose; 5-Thio-α,β-D-glucopyranose; 5-S-Glucose; 5-Deoxy-5-thio-D-glucose; 1,5-Anhydro-5-thio-D-glucitol; D-5-Thioglucose; 5-Thioglucose
EINECS	243-825-8

Quality Control

Our 5-Thio-D-Glucose is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data for identity, purity, and specific impurities. Our quality commitment ensures the material is suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.