Description

4-Hydroxy-3-Nitrocoumarin is a versatile nitrated coumarin derivative that serves as a key synthetic intermediate and functional building block. Its value lies in the strategic positioning of its nitro and hydroxyl groups, which enable a range of chemical transformations for creating complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients or advanced materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly those targeting anticoagulant, anti-inflammatory, or antimicrobial pathways.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the coumarin scaffold can contribute to specific biological activity.
• Fluorescent Probe & Dye Precursor: Acts as a starting material for synthesizing fluorescent tags, sensors, and organic dyes due to the inherent photophysical properties of the coumarin core.
• Organic Synthesis Building Block: Employed in heterocyclic and medicinal chemistry for constructing complex fused-ring systems via reactions involving its nitro and phenolic functional groups.
• Research & Development: Utilized in academic and industrial R&D settings for studying reaction mechanisms, developing new synthetic methodologies, and exploring structure-activity relationships.
• Material Science: Investigated as a monomer or additive for creating polymers with specific optical or electronic properties.

Basic Information

Product Name	4-Hydroxy-3-Nitrocoumarin
CAS No.	20261-31-8
Molecular Formula	C9H5NO5
Molecular Weight	207.14 g/mol
Synonyms	3-Nitro-4-hydroxycoumarin; 4-Hydroxy-3-nitro-2H-chromen-2-one; 3-Nitro-4-hydroxy-2H-chromen-2-one; 2H-1-Benzopyran-2-one, 4-hydroxy-3-nitro-; 4-Hydroxy-3-nitro-1-benzopyran-2-one; 4-Hydroxy-3-nitrocumarin; 3-Nitro-4-hydroxycumarin
EINECS	243-667-4

Quality Control

Our 4-Hydroxy-3-Nitrocoumarin is produced under a stringent quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets precise specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment, guaranteeing traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and tendency for easy oxidation, it is recommended to store the material under an inert atmosphere for long-term preservation and to minimize exposure to air and moisture upon opening.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	245 - 250 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.