Description

o-(4-Hydroxy-3-(131I)Iodophenyl)-3,5-Di(131I)Iodo-L-Tyrosine is a specialized, high-specific-activity radiopharmaceutical compound used as a precursor in nuclear medicine. This compound is critical for the development and production of diagnostic and therapeutic agents targeting specific biological pathways, particularly in oncology and endocrinology. It is primarily utilized by radiopharmaceutical manufacturers, advanced research institutions, and clinical laboratories engaged in the development of targeted radiotherapeutics and molecular imaging probes.

Application

• Radiopharmaceutical Synthesis: Key intermediate for the radiosynthesis of targeted therapeutic agents, especially for thyroid cancer and neuroendocrine tumors.
• Molecular Imaging Probe Development: Used in research to create novel PET (Positron Emission Tomography) or SPECT tracers for diagnostic applications.
• Targeted Radionuclide Therapy (TRT): Serves as a building block for compounds designed to deliver Iodine-131 radiation directly to cancer cells.
• Preclinical & Clinical Research: Essential for pharmacokinetic, biodistribution, and efficacy studies in animal models and early-phase human trials.
• Metabolic Pathway Tracing: Utilized in biochemical research to study tyrosine metabolism and iodine uptake mechanisms in vitro.

Basic Information

Product Name	o-(4-Hydroxy-3-(131I)Iodophenyl)-3,5-Di(131I)Iodo-L-Tyrosine
CAS No.	20196-64-9
Molecular Formula	C15H11131I3NO4
Molecular Weight	Contact for details
Synonyms	3,5-Diiodo-L-tyrosine, 3'-Iodo- Derivative; L-Tyrosine, o-(4-hydroxy-3-iodophenyl)-3,5-diiodo-; [131I]Iodo-L-Tyrosine derivative; Radioiodinated L-Tyrosine analog; I-131 Labeled Tyrosine Precursor; Therapeutic Iodine-131 Carrier Molecule; Targeted Radionuclide Therapy Intermediate
EINECS	Contact for details

Quality Control

Every batch of this high-purity radiochemical is manufactured and controlled under a strict quality management system. Specifications include rigorous testing for radiochemical purity (RCP) and radionuclidic purity (RNP) via validated HPLC and gamma spectroscopy methods. A comprehensive Certificate of Analysis (CoA) is provided with each shipment, detailing specific activity, purity levels, and analytical results. Production can adhere to cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended cold chain conditions (typically 2-8°C or as specified on the CoA) in a designated, shielded radiochemistry freezer or lead pot. The product is strictly light-sensitive (protect from all light exposure). Follow all applicable radiation safety protocols for handling and storage.

Specification

Item	Specification
Appearance	White to Off-White Solid
Identification (HPLC)	Conforms to Reference Standard
Radiochemical Purity (HPLC)	≥ 95%
Radionuclidic Purity (Gamma Spectroscopy)	≥ 99.9%
Specific Activity	Contact for details
Chemical Purity (HPLC)	≥ 98.0%
Solubility	Soluble in specific aqueous/organic mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.