Description

(Rs)-2-Amino-1,1,1-Trifluoropropane Hydrochloride is a high-purity chiral building block and key intermediate in advanced organic synthesis. This compound is valued for its trifluoromethyl group, which imparts unique metabolic stability and lipophilicity to target molecules. It is primarily required by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the CF3 group enhances biological activity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Fluorinated Amino Acid Analog: Employed in peptide mimetics and bio-conjugation to modify stability and binding properties.
• Material Science Research: A building block for fluorinated polymers and specialty materials with tailored surface properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for biochemical studies.

Basic Information

Product Name	(Rs)-2-Amino-1,1,1-Trifluoropropane Hydrochloride
CAS No.	2968-32-3
Molecular Formula	C3H7ClF3N
Molecular Weight	161.54 g/mol
Synonyms	1,1,1-Trifluoro-2-propanamine hydrochloride; 2-Amino-1,1,1-trifluoropropane HCl; (RS)-1,1,1-Trifluoro-2-aminopropane hydrochloride; rac-2-Amino-1,1,1-trifluoropropane hydrochloride; α-Trifluoromethyl ethylamine hydrochloride; 2-Amino-1,1,1-trifluoropropane monohydrochloride; 1,1,1-Trifluoro-2-propylamine hydrochloride; 2-Aminopropyl trifluoride hydrochloride
EINECS	Contact for details

Quality Control

Our (Rs)-2-Amino-1,1,1-Trifluoropropane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure compliance with exacting standards for research and production use. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98%), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99:1 Rs:Sr (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.