Description

Chlorodifluoroacetic Anhydride is a highly reactive acylating agent and a key fluorinated building block in organic synthesis. Its primary value lies in its ability to efficiently introduce the chlorodifluoroacetyl group, a critical motif for modifying the physicochemical properties of target molecules. This compound is essential for research and production in the pharmaceutical and agrochemical industries, where it is used to synthesize advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: Key reagent for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry for introducing metabolically stable motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the chlorodifluoroacetyl group enhances biological activity.
• Fluorinated Material Precursor: Serves as a building block for specialty polymers, surfactants, and liquid crystals that require specific fluorochemical properties.
• Peptide Modification: Employed in biochemical research for acylating amino groups to study protein structure and function.
• Organic Synthesis Reagent: A versatile acylating agent for laboratory-scale and pilot-scale synthesis of complex organic molecules.
• Dye and Pigment Manufacturing: Used in the synthesis of specialized fluorinated dyes with unique color fastness and stability.

Basic Information

Product Name	Chlorodifluoroacetic Anhydride
CAS No.	2834-23-3
Molecular Formula	C4Cl2F4O3
Molecular Weight	242.94 g/mol
Synonyms	2-Chloro-2,2-difluoroacetic Anhydride; Dichlorodifluoroacetic Anhydride; Chlorodifluoroacetic Acid Anhydride; Chlorodifluoroacetyl Anhydride; Difluorochloroacetic Anhydride; (Chlorodifluoroacetyl) Oxide; NSC 403058
EINECS	220-605-1

Quality Control

Our Chlorodifluoroacetic Anhydride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity verification, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.