Description

L-Serine,n-[(1,1-Dimethylethoxy)Carbonyl]-, Hydrazide is a protected serine derivative, specifically a Boc-protected serine hydrazide, which serves as a crucial building block in synthetic organic and peptide chemistry. Its primary value lies in its dual functionality, where the hydrazide group acts as a versatile handle for further chemical transformations, such as the synthesis of heterocycles or as a precursor to acyl azides via the Curtius rearrangement. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require high-purity, specialized intermediates for the development of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of peptide-based drugs and complex organic molecules targeting various therapeutic areas.
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis to construct specific peptide sequences.
• Heterocyclic Chemistry: Serves as a precursor for the generation of various nitrogen-containing heterocycles, which are core structures in many agrochemicals and pharmaceuticals.
• Bioconjugation & Labeling: The reactive hydrazide group can be utilized for site-specific conjugation with aldehydes or ketones, useful in creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Chemical Biology Research: Employed in the development of enzyme inhibitors, probes, and other tools for studying biological pathways and protein function.
• Fine Chemical Production: Acts as a specialized intermediate in the multi-step synthesis of high-value, low-volume fine chemicals and custom synthesis projects.

Basic Information

Product Name	L-Serine,n-[(1,1-Dimethylethoxy)Carbonyl]-, Hydrazide
CAS No.	2766-42-9
Molecular Formula	C8H17N3O4
Molecular Weight	219.24 g/mol
Synonyms	Boc-L-serine hydrazide; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxypropanehydrazide; N-Boc-L-serine hydrazide; Nα-Boc-L-serine hydrazide; Boc-Ser-NHNH2; tert-Butoxycarbonyl-L-serine hydrazide; L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-, hydrazide; Boc-Ser-OH-NHNH2
EINECS	Contact for details

Quality Control

Our L-Serine,n-[(1,1-Dimethylethoxy)Carbonyl]-, Hydrazide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates. Specifications can be tailored to meet the rigorous demands of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.