Description

[1S,(-)]-2',3',8',8'Aβ-Tetrahydro-6'-Hydroxy-3,5'-Dimethoxy-1'-Methylspiro[2,5-Cyclohexadiene-1,7'(1'H)-Cyclopenta[Ij]Isoquinoline]-4-One is a complex, high-purity organic compound belonging to the spiroisoquinoline alkaloid class, valued for its unique stereochemistry and functional groups. This compound serves as a critical advanced intermediate or reference standard in sophisticated organic synthesis and pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and conducting structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex bioactive molecules and potential drug candidates.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Medicinal Chemistry Research: Employed in the exploration of new chemical entities (NCEs) targeting neurological or other therapeutic areas, leveraging its spirocyclic and isoquinoline motifs.
• Asymmetric Synthesis: Serves as a substrate or template in catalytic asymmetric reactions due to its defined stereogenic center.
• Biochemical Research: Potential use as a tool compound for studying enzyme interactions or receptor binding in biochemical assays.
• Academic Research: Utilized in universities and research institutes for advanced studies in organic synthesis and natural product chemistry.

Basic Information

Product Name	[1S,(-)]-2',3',8',8'Aβ-Tetrahydro-6'-Hydroxy-3,5'-Dimethoxy-1'-Methylspiro[2,5-Cyclohexadiene-1,7'(1'H)-Cyclopenta[Ij]Isoquinoline]-4-One
CAS No.	2689-17-0
Molecular Formula	C22H23NO5
Molecular Weight	381.42 g/mol
Synonyms	(-)-Glaucine; (S)-Glaucine; L-Glaucine; 1,2,9,10-Tetramethoxyaporphine; Glaucine; NSC 343646; Fumarate (1:1); Glaucin; 5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo[de,g]quinoline
EINECS	Contact for details

Quality Control

Our [1S,(-)]-2',3',8',8'Aβ-Tetrahydro-6'-Hydroxy-3,5'-Dimethoxy-1'-Methylspiro[2,5-Cyclohexadiene-1,7'(1'H)-Cyclopenta[Ij]Isoquinoline]-4-One is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity ([α]D)	Specified optical rotation range provided per batch
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.