Description

Nps-Phe-Oh Dcha is a protected amino acid derivative, specifically N-(2-Nitrophenylsulfenyl)-L-phenylalanine, widely used as a key chiral building block in peptide synthesis. This compound is critical for researchers and manufacturers requiring high-purity intermediates to ensure the fidelity and yield of complex peptide sequences. It is primarily utilized by the pharmaceutical, biotechnology, and advanced research sectors for the development of therapeutic peptides, APIs, and novel bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as an Nα-protected phenylalanine derivative, where the Nps (2-Nitrophenylsulfenyl) group offers orthogonal protection strategies.
• Solution-Phase Peptide Synthesis: Used in the controlled, stepwise construction of peptides in solution, particularly for segments requiring specific stereochemical integrity.
• Pharmaceutical Intermediate: A crucial precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation and Labeling: Acts as a starting material for creating modified peptides with specific functional handles for labeling or conjugation purposes.
• Research & Development: Essential in academic and industrial R&D labs for exploring new peptide structures, peptidomimetics, and studying structure-activity relationships (SAR).
• Custom Peptide Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the reliable and scalable production of custom peptides.

Basic Information

Product Name	Nps-Phe-Oh Dcha
CAS No.	2688-22-4
Molecular Formula	C21H24N2O4S
Molecular Weight	400.49 g/mol
Synonyms	N-(2-Nitrophenylsulfenyl)-L-phenylalanine; N-2-Nitrophenylsulfenyl-L-phenylalanine; NPS-L-Phenylalanine; Nps-Phe-OH; (S)-2-((2-Nitrophenyl)thio)amino)-3-phenylpropanoic acid; L-Phenylalanine, N-[(2-nitrophenyl)thio]-; NPS-Phe; 2-Nitrophenylsulfenyl-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Nps-Phe-Oh Dcha is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including research and cGMP-grade material for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.