Description

n-Desmethylflunitrazepam CAS NO 2648-00-2 is a high-purity pharmaceutical intermediate and analytical reference standard. This compound is critical for research and development in medicinal chemistry, particularly in the study of benzodiazepine metabolism and pharmacology. It is primarily utilized by pharmaceutical R&D laboratories, forensic science institutions, and analytical service providers for method development and quality control.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis and research of novel benzodiazepine derivatives and related central nervous system (CNS) active compounds.
• Metabolite Reference Standard: Used as an analytical standard in forensic and clinical toxicology for the identification and quantification of flunitrazepam metabolites in biological samples.
• Pharmacological Research: Employed in preclinical studies to investigate the structure-activity relationships (SAR), metabolic pathways, and pharmacokinetic profiles of benzodiazepines.
• Analytical Method Development: Serves as a certified reference material (CRM) for calibrating equipment and validating analytical methods such as HPLC, LC-MS, and GC-MS in quality control laboratories.
• Regulatory Compliance Testing: Essential for laboratories conducting impurity profiling and ensuring compliance with regulatory guidelines for pharmaceutical substances.

Basic Information

Product Name	n-Desmethylflunitrazepam
CAS No.	2648-00-2
Molecular Formula	C₁₅H₁₀FN₃O₃
Molecular Weight	299.26 g/mol
Synonyms	7-Amino-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; Norflunitrazepam; Desmethylflunitrazepam; Flunitrazepam Impurity C; Flunitrazepam Metabolite; 1-Desmethylflunitrazepam; Ro 07-5220; 5-(2-Fluorophenyl)-7-amino-1,3-dihydro-2H-1,4-benzodiazepin-2-one
EINECS	Contact for details

Quality Control

Our n-Desmethylflunitrazepam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity determination by chromatographic techniques (HPLC). We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing assay, impurity profile, and residual solvents to meet the stringent requirements of research and regulatory applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.