Description

n-Me-Aib-Oh Hcl CAS NO 2566-34-9 is a protected amino acid derivative, specifically the hydrochloride salt of N-methylated 2-aminoisobutyric acid (Aib). This compound is a crucial building block in advanced organic synthesis, particularly for the construction of peptides with modified backbones to enhance metabolic stability and alter conformational properties. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers developing novel therapeutic peptides and peptidomimetics.

Application

• Peptide Synthesis: As a key intermediate for incorporating N-methylated Aib residues into peptide chains to induce specific helical conformations and improve bioavailability.
• Pharmaceutical Research: Used in the R&D of new drug candidates, especially in oncology and metabolic disease research where stabilized peptide structures are critical.
• Peptidomimetic Design: Serves as a scaffold for creating non-natural peptide analogs that mimic biological activity while resisting enzymatic degradation.
• Bioconjugation: Acts as a specialized linker or spacer molecule in the synthesis of complex biomolecular conjugates for diagnostic or therapeutic applications.
• Academic & Industrial R&D: Employed in chemical biology studies to investigate protein-protein interactions and structure-activity relationships (SAR).
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing custom peptides and specialized amino acid derivatives for clients.

Basic Information

Product Name	n-Me-Aib-Oh Hcl
CAS No.	2566-34-9
Molecular Formula	C6H13NO2·HCl
Molecular Weight	167.63 g/mol (Free base: 131.17 g/mol)
Synonyms	2-(Methylamino)-2-methylpropanoic acid hydrochloride; N-Methyl-2-aminoisobutyric acid hydrochloride; N-Methyl-Aib-OH·HCl; (2-Methylamino-2-methyl)propionic acid hydrochloride; 2-Methylamino-isobutyric acid HCl; N-Me-Aib-OH·HCl; N-Methylaminoisobutyric acid HCl; α-(Methylamino)isobutyric acid hydrochloride
EINECS	Contact for details

Quality Control

Our n-Me-Aib-Oh Hcl is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all specified parameters to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.