Description

2,4,6-Trinitrobenzenesulfonic Acid is a highly reactive aromatic sulfonic acid derivative, known for its strong electrophilic character. This compound is a critical reagent in organic synthesis, particularly valued for its role in the formation of covalent bonds with nucleophiles. It is essential for research and industrial applications in pharmaceutical development, materials science, and biochemical analysis, where precise chemical modification is required.

Application

• Peptide and Protein Modification: A key reagent for the quantitative determination of amino groups, particularly in the TNBS assay for primary amines.
• Cross-linking Agent: Used in the synthesis of polymers and hydrogels, creating stable networks for advanced material applications.
• Pharmaceutical Intermediate: Serves as a building block in the synthesis of more complex active pharmaceutical ingredients (APIs) and fine chemicals.
• Bioconjugation Chemistry: Facilitates the labeling and attachment of molecules to proteins, antibodies, and other biomolecules for diagnostic and research purposes.
• Analytical Chemistry: Employed as a derivatization agent to enhance the detection and analysis of compounds containing nucleophilic sites.
• Dye and Pigment Synthesis: Acts as a precursor in the manufacture of specialized colorants and functional dyes.

Basic Information

Product Name	2,4,6-Trinitrobenzenesulfonic Acid
CAS No.	2508-19-2
Molecular Formula	C6H3N3O9S
Molecular Weight	293.17 g/mol
Synonyms	TNBS; TNBSA; Picrylsulfonic Acid; 2,4,6-Trinitrobenzenesulfonic Acid Hydrate; 1-Hydroxy-2,4,6-trinitro-3-benzenesulfonic acid; Trinitrobenzenesulfonic Acid Solution; 3-Carboxy-1,3,5-trinitrobenzene; 2,4,6-Trinitrophenylsulfonic Acid
EINECS	219-734-8

Quality Control

Our 2,4,6-Trinitrobenzenesulfonic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from incompatible materials such as bases, reducing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solution
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.