Description

L-Methionine Methyl Ester Hydrochloride is a protected derivative of the essential amino acid L-Methionine, widely used as a key chiral building block in organic synthesis. Its primary value lies in providing a reactive ester group that facilitates peptide coupling and other transformations while protecting the carboxylic acid functionality. This high-purity intermediate is critically needed by pharmaceutical R&D and production teams for synthesizing peptides, peptidomimetics, and other bioactive compounds, as well as by researchers in life sciences and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate methionine residues with a protected carboxyl group.
• Bioconjugation & Labeling: Serves as a starting material for preparing methionine derivatives used in protein labeling and bioconjugation techniques.
• Research & Development: Employed in academic and industrial R&D for exploring new synthetic methodologies and developing novel therapeutic candidates.
• Fine Chemical Production: Acts as a building block for manufacturing specialized fine chemicals, catalysts, and ligands.
• Nutraceutical & Cosmetic Ingredient Synthesis: Used in the production of specialized amino acid derivatives for advanced nutritional and cosmetic formulations.

Basic Information

Product Name	L-Methionine Methyl Ester Hydrochloride
CAS No.	2491-18-1
Molecular Formula	C6H14ClNO2S
Molecular Weight	199.70 g/mol
Synonyms	L-Methionine methyl ester HCl; (S)-2-Amino-4-(methylthio)butanoic acid methyl ester hydrochloride; Methyl L-methioninate hydrochloride; Methionine methyl ester hydrochloride; H-Met-OMe·HCl; L-Met-OMe·HCl; Methyl (2S)-2-amino-4-(methylsulfanyl)butanoate hydrochloride
EINECS	219-672-5

Quality Control

Our L-Methionine Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing specific results for identity, assay, optical rotation, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	+20.0° to +24.0° (c=1 in H2O)
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.