Description

4-(Difluoromethylsulfonyl)Chlorobenzene is a versatile and high-purity organosulfur building block, essential for advanced chemical synthesis. Its unique structure, featuring both a reactive sulfonyl chloride group and a difluoromethyl substituent on an aromatic ring, makes it a critical intermediate for introducing specific functionalities into target molecules. This compound is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those requiring sulfonamide or difluoromethyl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethylsulfonyl group can contribute to improved efficacy and environmental profile.
• Material Science Research: Serves as a monomer or precursor for synthesizing specialized polymers, liquid crystals, or organic electronic materials with tailored properties.
• Cross-Coupling Reactions: The chlorobenzene moiety allows for participation in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Sulfonamide Library Production: Ideal for high-throughput synthesis of diverse sulfonamide libraries for biological screening in drug discovery programs.
• Fluorine Chemistry: A valuable reagent for introducing fluorine atoms into organic molecules, a common strategy in modern medicinal chemistry to modulate lipophilicity and potency.

Basic Information

Product Name	4-(Difluoromethylsulfonyl)Chlorobenzene
CAS No.	2488-53-1
Molecular Formula	C7H5ClF2O2S
Molecular Weight	226.63 g/mol
Synonyms	1-Chloro-4-(difluoromethylsulfonyl)benzene; p-(Difluoromethylsulfonyl)chlorobenzene; 4-Chlorophenyl difluoromethyl sulfone; Benzene, 1-chloro-4-[(difluoromethyl)sulfonyl]-; α,α-Difluoro-4-chlorobenzenemethanesulfonic acid sulfone; 4-Chloro-α,α-difluorobenzenemethanesulfonic acid sulfone
EINECS	Contact for details

Quality Control

Every batch of 4-(Difluoromethylsulfonyl)Chlorobenzene is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and compliance with your internal quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.