Description

5-Fluorosulfonyl-2-Methoxybenzoic Acid is a high-value, multi-functional aromatic building block characterized by its reactive sulfonyl fluoride and carboxylic acid groups. This compound matters for its pivotal role in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research where it serves as a key intermediate for introducing fluorosulfonyl moieties. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of sulfonamide-based drugs and targeted covalent inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the bioactivity of the fluorosulfonyl group.
• Chemical Biology & Proteomics: Serves as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent probes for target identification and validation.
• Material Science: Employed in the synthesis of specialized polymers and advanced organic materials requiring sulfonyl fluoride functionalization.
• Cross-Coupling Reactions: Acts as a substrate in various metal-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Sulfonyl Fluoride Chemistry: A prime starting material for SuFEx (Sulfur Fluoride Exchange) click chemistry, enabling the rapid and reliable formation of sulfonate esters and sulfonamides.

Basic Information

Product Name	5-Fluorosulfonyl-2-Methoxybenzoic Acid
CAS No.	2488-50-8
Molecular Formula	C8H7FO5S
Molecular Weight	234.20 g/mol
Synonyms	2-Methoxy-5-fluorosulfonylbenzoic Acid; 5-(Fluorosulfonyl)-2-methoxybenzoic Acid; 2-Methoxy-5-sulfofluorobenzoic Acid; Benzoic acid, 5-(fluorosulfonyl)-2-methoxy-; 5-Fluorosulfonyl-o-anisic Acid
EINECS	Contact for details

Quality Control

Our 5-Fluorosulfonyl-2-Methoxybenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry conditions to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by titration)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.