Description

H-D-Trp-Oet·Hcl is a protected derivative of the essential amino acid tryptophan, specifically the D-enantiomer esterified with ethanol and presented as the hydrochloride salt. This high-purity chiral building block is critical for the synthesis of complex peptides and peptidomimetics where stereochemical control is paramount. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic probes, and advanced biochemical tools.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs, hormones, and enzyme inhibitors.
• Biochemical Research: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the D-tryptophan residue into custom peptide sequences for structure-activity relationship (SAR) studies.
• Proteomics & Diagnostics: Incorporation into labeled peptides or affinity tags for mass spectrometry, protein interaction studies, and diagnostic assay development.
• Academic Research: Serves as a standard or reagent in studies focusing on chirality, enzyme specificity, and metabolic pathways involving tryptophan.
• Cosmeceutical Peptides: Potential use in the synthesis of bioactive peptides for advanced skincare formulations.

Basic Information

Product Name	H-D-Trp-Oet·Hcl
CAS No.	2299-28-7
Molecular Formula	C13H17ClN2O2
Molecular Weight	268.74 g/mol
Synonyms	D-Tryptophan ethyl ester hydrochloride; (R)-2-Amino-3-(1H-indol-3-yl)propanoic acid ethyl ester hydrochloride; Ethyl D-tryptophanate hydrochloride; H-D-Trp-OEt HCl; D-Trp-OEt·HCl; Ethyl (R)-2-amino-3-(3-indolyl)propionate hydrochloride; Fmoc-D-Trp(Boc)-OEt (precursor related name); D-Tryptophan ethyl ester HCl salt
EINECS	Contact for details

Quality Control

Our H-D-Trp-Oet·Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98.5% by HPLC), chiral purity, and impurity profiles. We support compliance with cGMP guidelines for advanced pharmaceutical intermediates, and specifications can be aligned with client-specific pharmacopeial requirements (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.