Description

Bis(3-Fluoropropionic)Anhydride is a specialized fluorinated anhydride used as a key building block in advanced organic synthesis. This compound is valued for its ability to introduce the 3-fluoropropionyl moiety, a functional group of significant interest in medicinal chemistry and materials science. It is primarily sought by researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical reagent for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and environmental persistence.
• Polymer & Material Science: Serves as a monomer or modifier in the creation of fluorinated polymers, coatings, and specialty materials with unique surface properties, chemical resistance, or dielectric characteristics.
• Peptide & Protein Modification: Employed to fluorinate specific amino acid side chains or terminal groups in peptides and proteins for biochemical research and probe development.
• Liquid Crystal & OLED Materials: Acts as a key synthetic precursor for fluorinated components in electronic display and lighting technologies.
• Cross-coupling Reagent: Utilized in various metal-catalyzed cross-coupling reactions to construct complex fluorinated molecular architectures.

Basic Information

Product Name	Bis(3-Fluoropropionic)Anhydride
CAS No.	2266-47-9
Molecular Formula	C6H6F2O3
Molecular Weight	164.11 g/mol
Synonyms	3-Fluoropropionic Anhydride; Bis(3-fluoropropanoyl) Oxide; 3,3'-(Oxydicarbonyl)dipropanoic Acid Difluoride; Difluoropropionic Anhydride; Propanoic Acid, 3-fluoro-, 1,1'-anhydride; 3-Fluoropropanoic Anhydride; 3-Fluoropropionyl Anhydride; 2266-47-9 (CAS)
EINECS	Contact for details

Quality Control

Our Bis(3-Fluoropropionic)Anhydride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay by GC/HPLC, identity confirmation (IR, NMR), and impurity profiling, to ensure it meets the high-purity standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
3-Fluoropropionic Acid	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.