Description

4-Ethynyl-Phenol is a versatile phenolic compound featuring a terminal alkyne functional group, making it a valuable building block in advanced organic synthesis. Its bifunctional nature allows for selective modifications, enabling the creation of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for developing active pharmaceutical ingredients (APIs), specialty polymers, and liquid crystal materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in kinase inhibitor and oncology research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for specialty polymers, resins, and high-performance liquid crystal displays (LCDs).
• Click Chemistry: The terminal alkyne group is ideal for Huisgen 1,3-dipolar cycloaddition reactions, facilitating efficient bioconjugation and material surface functionalization.
• Organic Electronic Materials: Employed in the synthesis of conjugated molecules for organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research & Development: A fundamental reagent in academic and industrial R&D for exploring new synthetic methodologies and creating molecular libraries.

Basic Information

Product Name	4-Ethynyl-Phenol
CAS No.	2200-91-1
Molecular Formula	C8H6O
Molecular Weight	118.13 g/mol
Synonyms	4-Hydroxyphenylacetylene; p-Ethynylphenol; 1-Ethynyl-4-hydroxybenzene; 4-(Ethynyl)phenol; 4-Ethynyl-1-hydroxybenzene; p-Hydroxyphenylacetylene; 4-Hydroxybenzeneacetylene
EINECS	218-618-7

Quality Control

Our 4-Ethynyl-Phenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area. Recommended long-term storage temperature is 2-8°C. The compound is easily oxidized; ensure containers are sealed properly after each use to minimize exposure to air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.