Description

2,2,5,5-Tetramethyl-3-Pyrrolin-1-Oxyl-3-Carboxylic Acid CAS NO 2154-67-8 is a stable nitroxide radical, specifically a carboxylic acid-functionalized TEMPO derivative. This compound is a critical building block and spin label in advanced materials science and biochemistry research. It is primarily sought after by R&D and production teams in the pharmaceutical, polymer, and analytical chemistry sectors for its unique paramagnetic properties and reactivity.

Application

• Spin Labeling Agent: Used in Electron Paramagnetic Resonance (EPR) and Site-Directed Spin Labeling (SDSL) studies to probe protein structure, dynamics, and conformational changes.
• Polymerization Mediator/Initiator: Serves as a controlled radical polymerization agent, such as in Nitroxide-Mediated Polymerization (NMP), for synthesizing polymers with precise architecture.
• Organic Synthesis Intermediate: The carboxylic acid group allows for further functionalization, making it a versatile precursor for synthesizing more complex nitroxide radicals and bioconjugates.
• Antioxidant & Stabilizer Research: Investigated for its radical scavenging properties in the development of stabilizers for plastics, fuels, and lubricants.
• MRI Contrast Agent Development: Explored as a component in the design of novel contrast agents for magnetic resonance imaging (MRI).
• Catalysis: Employed as a co-catalyst or redox mediator in selective oxidation reactions in organic chemistry.

Basic Information

Product Name	2,2,5,5-Tetramethyl-3-Pyrrolin-1-Oxyl-3-Carboxylic Acid
CAS No.	2154-67-8
Molecular Formula	C10H16NO3
Molecular Weight	198.24 g/mol
Synonyms	3-Carboxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxy; 3-Carboxy-PROXYL; 3-Carboxy-2,2,5,5-tetramethylpyrrolidine-1-oxyl; 3-Carboxy-2,2,5,5-tetramethylpyrrolidin-1-oxyl; 3-Carboxy-TEMPO; 1-Oxyl-2,2,5,5-tetramethyl-3-pyrroline-3-carboxylic acid; 3-Carboxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxy free radical; 3-CP
EINECS	218-452-7

Quality Control

Our 2,2,5,5-Tetramethyl-3-Pyrrolin-1-Oxyl-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and EPR for radical content verification, to ensure it meets the high standards required for research and industrial applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. Keep away from strong oxidizing agents and reducing agents.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
EPR Assay	≥ 97.0% (Radical content)
Melting Point	185 - 190 °C (dec.)
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.