Description

α-D-Glucosamine 1-Phosphate is a key phosphorylated monosaccharide derivative essential for biochemical research and synthesis. This compound serves as a critical intermediate in the enzymatic and chemical synthesis of complex carbohydrates, glycoconjugates, and nucleotide sugars. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies focused on glycoscience, metabolic pathway studies, and the production of high-value biochemicals.

Application

• Biochemical Research: Critical substrate for studying enzymes like glucosamine-1-phosphate acetyltransferase and other glycosyltransferases involved in amino sugar metabolism.
• Glycoconjugate Synthesis: Serves as a vital building block (donor substrate) in the enzymatic synthesis of oligosaccharides, glycoproteins, and glycolipids.
• Pharmaceutical Intermediates: Used in the research and development of novel therapeutic agents, including antibiotics and anti-inflammatory drugs that target carbohydrate metabolism.
• Nucleotide Sugar Production: Acts as a precursor in the synthesis of UDP-N-acetylglucosamine (UDP-GlcNAc) and other activated sugar nucleotides.
• Metabolic Pathway Analysis: Employed in cell culture and in vitro studies to investigate the hexosamine biosynthesis pathway and its role in cellular signaling.
• Enzyme Activity Assays: Used as a standard or substrate in high-throughput screening (HTS) assays to identify enzyme inhibitors or activators.

Basic Information

Product Name	α-D-Glucosamine 1-Phosphate
CAS No.	2152-75-2
Molecular Formula	C6H14NO8P
Molecular Weight	259.15 g/mol
Synonyms	D-Glucosamine 1-Phosphate; Glucosamine-1-phosphate; α-D-Glucosamine 1-Phosphate; 2-Amino-2-deoxy-α-D-glucopyranose 1-phosphate; 2-Amino-2-deoxy-α-D-glucose 1-phosphate; GlcN-1-P; (3R,4R,5S,6R)-3-Amino-6-(hydroxymethyl)oxane-2,4,5-triol dihydrogen phosphate
EINECS	218-427-7

Quality Control

Our α-D-Glucosamine 1-Phosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and specific tests for moisture and related substances. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For extended storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Specific Rotation	+70° to +80° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.