Description

cis-2,5-Bishydroxymethyl-Tetrahydrofuran is a versatile bifunctional chiral building block featuring a tetrahydrofuran core with hydroxymethyl groups at the 2 and 5 positions. This compound is highly valued for its ability to introduce both rigidity and functional handles into complex molecular architectures, serving as a key intermediate in advanced organic synthesis. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of nucleoside analogs, antiviral drugs, and other bioactive molecules.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators requiring specific stereochemistry.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for producing specialty polyethers, polyesters, and biodegradable polymers with tailored properties.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Employed in the multistep synthesis of flavors, fragrances, and other high-value specialty chemicals.
• Academic & Industrial R&D: A valuable tool for medicinal chemistry and material science research exploring new molecular entities.

Basic Information

Product Name	cis-2,5-Bishydroxymethyl-Tetrahydrofuran
CAS No.	2144-40-3
Molecular Formula	C6H12O3
Molecular Weight	132.16 g/mol
Synonyms	(2R,5S)-2,5-Bis(hydroxymethyl)tetrahydrofuran; (2S,5R)-2,5-Bis(hydroxymethyl)tetrahydrofuran; cis-Tetrahydrofuran-2,5-dimethanol; 2,5-Bis(hydroxymethyl)tetrahydrofuran (cis-); THF-2,5-dimethanol; 2,5-Di(hydroxymethyl)tetrahydrofuran; 2144-40-3; Tetrahydrofuran-2,5-dimethanol
EINECS	218-394-7

Quality Control

Our cis-2,5-Bishydroxymethyl-Tetrahydrofuran is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (cis-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.