Description

o-(4-Nitrobenzyl)Hydroxylamine Hydrochloride is a specialized organic salt compound widely used as a key synthetic intermediate and protecting group reagent. Its value lies in its ability to introduce the o-nitrobenzyloxy (ONB) moiety, which is photolabile, making it crucial for the controlled release of active molecules in advanced applications. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and life science sectors engaged in photochemistry, prodrug development, and peptide synthesis.

Application

• Photolabile Protecting Group: Serves as a critical reagent for introducing the o-nitrobenzyloxy (ONB) protecting group in organic synthesis, enabling the light-triggered deprotection of alcohols, amines, and carboxylic acids.
• Pharmaceutical Intermediate: Used in the research and development of prodrugs and targeted drug delivery systems where controlled, site-specific activation is required.
• Peptide Synthesis: Employed as a building block or protecting group agent in the synthesis of complex peptides and biomolecules.
• Agrochemical Research: Acts as an intermediate in the development of novel pesticides and herbicides with advanced release mechanisms.
• Material Science: Utilized in the creation of photo-responsive polymers and smart materials that change properties upon light exposure.
• Bioconjugation Chemistry: Facilitates the development of photo-cleavable linkers for attaching labels, drugs, or probes to proteins and other biomolecules.

Basic Information

Product Name	o-(4-Nitrobenzyl)Hydroxylamine Hydrochloride
CAS No.	2086-26-2
Molecular Formula	C7H9N2O3·HCl
Molecular Weight	218.62 g/mol
Synonyms	o-Nitrobenzylhydroxylamine hydrochloride; 2-(4-Nitrobenzyloxy)amine hydrochloride; ONBH·HCl; (4-Nitrobenzyl)hydroxylamine hydrochloride; 4-Nitrobenzyloxyamine hydrochloride; 1-(4-Nitrophenyl)methoxyamine hydrochloride; Hydroxylamine, O-[(4-nitrophenyl)methyl]-, hydrochloride; NSC 403697
EINECS	Contact for details

Quality Control

Our o-(4-Nitrobenzyl)Hydroxylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets high-purity standards suitable for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.