Description

(1S,2R)-2-(4-Fluoro-Phenyl)-Cyclopropylamine Hydrochloride is a high-purity chiral building block of significant importance in modern pharmaceutical synthesis. This compound serves as a critical intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the discovery and scale-up of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of advanced drug candidates, especially for neurological and psychiatric applications.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in the development of robust, kilogram-to-ton scale manufacturing routes for clinical and commercial API production.
• Reference Standard: Used as an analytical standard for quality control and regulatory filing (e.g., FDA, EMA) of related pharmaceutical products.

Basic Information

Product Name	(1S,2R)-2-(4-Fluoro-Phenyl)-Cyclopropylamine Hydrochloride
CAS No.	1990505-73-1
Molecular Formula	C9H11ClFN
Molecular Weight	187.64 g/mol
Synonyms	(1S,2R)-rel-2-(4-Fluorophenyl)cyclopropanamine hydrochloride; trans-2-(4-Fluorophenyl)cyclopropylamine hydrochloride (enantiomer); 2-(p-Fluorophenyl)cyclopropylamine HCl; 4-Fluoro-trans-2-phenylcyclopropylamine hydrochloride; (1S,2R)-2-(4-Fluorophenyl)cyclopropan-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our (1S,2R)-2-(4-Fluoro-Phenyl)-Cyclopropylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure compliance with high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.