Description

Methanesulfonato(Di-tert-Butyl(2',4',6'-Triispropyl-3,6-Dimethoxybiphenyl-2-Yl)Phosphine)(2'-Methylamino-1,1'-Biphenyl-2-Yl)Palladium(II) is a highly specialized, air-stable palladium catalyst complex designed for demanding cross-coupling reactions. Its value lies in the unique Buchwald-type biarylphosphine ligand, which provides exceptional activity and selectivity, particularly for challenging substrates in pharmaceutical synthesis. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance catalysts for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A premier catalyst for Buchwald-Hartwig amination and Suzuki-Miyaura cross-coupling reactions in API (Active Pharmaceutical Ingredient) development.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring the formation of C-N and C-C bonds under mild conditions.
• Material Science: Facilitates the polymerization and functionalization of organic electronic materials, such as those used in OLEDs and conductive polymers.
• Process Chemistry Optimization: Enables more efficient, scalable routes for the industrial manufacture of fine chemicals with lower catalyst loadings and higher yields.
• Academic & Industrial R&D: A critical tool for methodological development in organic synthesis and exploring new chemical spaces.

Basic Information

Product Name	Methanesulfonato(Di-tert-Butyl(2',4',6'-Triispropyl-3,6-Dimethoxybiphenyl-2-Yl)Phosphine)(2'-Methylamino-1,1'-Biphenyl-2-Yl)Palladium(II)
CAS No.	1980785-05-4
Molecular Formula	C53H78NO5PPdS
Molecular Weight	955.60 g/mol
Synonyms	Buchwald Palladium Precatalyst G4; Methanesulfonato Adduct of Pd-PEPPSI-IPent; Pd-PEPPSI-IPent Mesylate; Palladium(II) Methanesulfonate Complex with Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine and 2'-methylamino-[1,1'-biphenyl]-2-yl; [Pd(IPent)(2-MeNH-biphenyl)](OMs); PEPPSI-IPent Pd Catalyst; Pd-PEPPSI-IPent(OMs); Palladium G4 Catalyst
EINECS	Contact for details

Quality Control

Every batch of our palladium catalyst is synthesized and handled under strict inert atmosphere conditions to preserve its activity. We employ advanced analytical techniques including NMR, HPLC, and elemental analysis to verify identity, purity, and metal content. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and residual solvent levels is provided with each shipment to ensure it meets the stringent requirements for cGMP and process chemistry applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will degrade catalytic performance.

Specification

Item	Specification
Appearance	Orange to brown crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Pd Content (ICP-OES)	10.5 - 11.5 %
Solvent Residues (GC)	Meet ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.