Description

Ethyl 3-Aminobicyclo[1.1.1]pentane-1-carboxylate hydrochloride is a high-purity, pharmaceutically relevant building block featuring the unique and highly sought-after bicyclo[1.1.1]pentane (BCP) scaffold. This compound is critical for medicinal chemists seeking to improve the metabolic stability, lipophilicity, and three-dimensional character of drug candidates, particularly in the development of small molecule therapeutics. It is primarily utilized in research and development for proteolysis-targeting chimeras (PROTACs), kinase inhibitors, and other targeted therapies where its rigid, sp3-rich structure offers distinct advantages over traditional aromatic bioisosteres.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• PROTAC & Molecular Glue Development: Used to incorporate the BCP motif into linkers or warheads to enhance the physicochemical properties and efficacy of targeted protein degraders.
• Medicinal Chemistry & Drug Discovery: Employed as a saturated bioisostere for para-substituted benzene rings or tert-butyl groups to reduce metabolic clearance and improve pharmacokinetic profiles.
• Chemical Biology Probes: Serves as a scaffold for creating tool compounds to study protein function and biological pathways.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with enhanced stability.
• Material Science Exploration: Investigated as a monomer or precursor for novel polymers with unique structural properties.

Basic Information

Product Name	Ethyl 3-Aminobicyclo[1.1.1]pentane-1-carboxylate hydrochloride
CAS No.	1980049-72-6
Molecular Formula	C9H16ClNO2
Molecular Weight	205.68 g/mol
Synonyms	Ethyl 3-aminobicyclo[1.1.1]pentane-1-carboxylate HCl; 1-Carboxylic acid, 3-aminobicyclo[1.1.1]pentane-1-, ethyl ester, hydrochloride; 3-Amino-BCP-1-carboxylic acid ethyl ester hydrochloride; BCP-NH2 ethyl ester hydrochloride; Ethyl 3-amino-BCP-1-carboxylate hydrochloride; 1-(Ethoxycarbonyl)bicyclo[1.1.1]pentan-3-amine hydrochloride
EINECS	Contact for details

Quality Control

Our Ethyl 3-Aminobicyclo[1.1.1]pentane-1-carboxylate hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.