Description

5-Bromoquinoline-3-Carbonitrile is a versatile brominated quinoline derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a bromine substituent and a nitrile group, makes it a valuable precursor for constructing complex heterocyclic systems and functionalized molecules. This high-purity intermediate is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other therapeutic agents.
• Agrochemical Synthesis: Used as a precursor for creating advanced crop protection agents and pesticides with specific biological activity.
• Material Science Research: Serves as a building block for synthesizing organic ligands, coordination complexes, and functional polymers with tailored electronic or optical properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and enzyme functions.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form more complex biaryl structures.
• Nitrile Functionalization: The cyano group provides a handle for further chemical transformations into amides, acids, tetrazoles, and other heterocycles.

Basic Information

Product Name	5-Bromoquinoline-3-Carbonitrile
CAS No.	1974296-18-8
Molecular Formula	C10H5BrN2
Molecular Weight	233.07 g/mol
Synonyms	3-Cyano-5-bromoquinoline; 5-Bromo-3-quinolinecarbonitrile; Quinoline, 5-bromo-3-cyano-; 5-Bromoquinoline-3-carbonitrile; 5-Bromo-3-cyanquinoline
EINECS	Contact for details

Quality Control

Our 5-Bromoquinoline-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance records.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.